十三水群
PerkinElmer

生物治療

OF

珀金埃爾默提供簡單的工作流程解決方案,確保生物治療研究和患者安全所需的一致、可復驗結果。

我們與世界領先的制藥、生物技術、合同研究組織合作,協助研發制造新型藥物和疫苗。我公司在以下領域具有豐富經驗:

  • 抗體表征和測試
  • 靶標確認
  • 免疫原性/安全測試
  • 抗體篩選
  • 污染和質控測試
  • 細胞表征
  • 批次放行驗證
  • 功能性測試
  • 疫苗研發
  • PK和功效試驗

僅供研究使用。不適用于診斷程序。

Target Identification
Target Identification

靶標確定

在發現新生物治療藥物的早期階段確定相關疾病標靶。徹底驗證每個標靶,避免潛在的下游問題。我公司憑借試管和體內結合的方法,可提供最準確的標靶相關人類疾病的預測。
  • 試管標靶驗證細胞成像
  • 標靶發現活體內成像
  • 活體外標靶驗證組織成像
Protein Antibody
Protein Antibody

克隆和表達

我們提供一系列微流體、ELISA替代、成像、信息、檢測和自動化解決方案,幫助您簡化克隆和表達過程中各階段的工作流程,提高生成的數據的質量:
  • 克隆選擇
  • 蛋白質純化
  • 功能篩選
  • 生物分析表征
General laboratory
General laboratory

臨床前安全

通過高質量、可復驗的測試數據,準確定量抗藥物抗體(ADA)和藥代動力學(PK)/藥效學(PD)。無論您的研究涉及單克隆抗體(mAb)、蛋白質或多肽,我公司提供的多種免疫原性、中和抗體(NAb)和PD/PK測試解決方案均可幫助您簡化工作流程。
Pipetting
Pipetting

生產和質控

確定過程和產品相關雜質,確保其不會影響生物治療藥物或疫苗研究的質量和安全性。

LabChip?微流體技術可對藥用蛋白質進行快速可復驗純度分析,并可檢測識別濃度峰值低至5ng/μL的低濃度雜質,從而加速生產和質控過程。

產品與服務 (186)
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1-12 的 186 產品與服務

  • EnSight Multimode Plate Reader

    EnSight 多模式讀板儀

    EnSight? 多模式讀板儀是一臺整合了多標記、無標記和顯微成像技術的桌面式一體化檢測平臺。其整孔成像&在線數據分析速度非常快,可以在五分鐘內完成384孔板整板的圖像獲取及分析。該儀器采用預置模塊化設計,結合基于Kaleido軟件的數據采集和分析流程,是一臺真正的全能且高產的多模式讀板儀。
  • 1000x1000_Opera_Phenix

    Opera Phenix 高內涵系統

    Opera Phenix?高內涵系統是目前最受期待的高內涵共聚焦技術方案。依賴將近20年的頂尖高內涵產品opera高內涵成像系統積累的豐富成像和應用經驗,新一代的opera phenix系統系統專為高內涵表型篩選以及復雜的疾病模型量身打造,例如活細胞、原代細胞,細胞微組織。
  • FMT In Vivo Imaging Instrument

    FMT 1000 In Vivo Imaging System

    The FMT? 1000 is an entry level 3D fluorescence tomographic system with the ability to quantitate a single fluorophore at a time.
  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS 小動物活體成像系統

    IVIS? Lumina XRMS III是PerkinElmer最新推出的二維多模式活體成像系統,具備最高靈敏度的生物發光、多光譜熒光、放射性同位素和X光活體成像功能。
  • LabChip GXII Touch System

    LabChip GXII Touch Protein Characterization System

    LabChip GXII Touch系統是是準確、可重復的蛋白樣本分析完整解決方案。LabChip GXII Touch HT利用微流體技術減少了處理耗時的SDS聚丙烯酰胺凝膠電泳的需求,并且以更少的時間和金錢來提供卓越的結果。
  • FMT In Vivo Imaging Instrument

    FMT 4000 In Vivo Imaging System

    The FMT 4000 fluorescence tomography imaging system provides the greatest utility of the FMT Systems with the ability to quantitate up to four fluorophores simultaneously. It comes with four excitation laser channels (635, 680, 750, & 790 nm).
  • EnVision 2105 multimode plate reader

    EnVision 多模式讀板儀

    EnVision 多模式讀板儀在所有檢測模式下都能提供最快的檢測速度、超高通量及最高的靈敏度,為您的高通量篩選提供可靠的儀器及結果,以滿足您日益加速的新實驗需求。
  • JANUS G3 Btx Pro-Plus

    JANUS G3 BioTx Pro Plus工作站

    JANUS? G3 Bio Tx Pro Plus為高通量工藝開發提供完全的“無人值守的”自動化,實現從珍貴的起始材料及有限資源中獲取更多數據。
  • 1000x1000_Operetta

    Operetta CLS 高內涵系統

    Operetta CLS? 系統幫助您探索常規實驗與復雜創新實驗中的生物學信息。通過一系列創新技術的有機結合,Operetta CLS? 同時滿足精細細胞細節成像對高速、高靈敏度、高分辨率檢測多方面的需求。同時,憑借功能強大的Harmony 4.5版軟件,Operetta CLS? 可幫助您發現并定量細微的細胞表型改變。
  • IVIS Spectrum In Vivo Imaging System

    IVIS Spectrum 小動物活體成像系統

    IVIS? Spectrum 小動物活體光學成像系統是全球首臺同時具備生物發光、熒光、化學發光及切倫科夫二維/三維成像功能的系統,代表了目前活體光學成像技術的最高水平。
  • VictorX_ImageA_320px

    VICTOR 多模式讀板儀

    新一代的 VICTOR X 系列多模式讀板儀為各種規模的實驗室提供集靈活性、高速度和高性能于一體的解決方案。
  • G8 PET/CT benchtop scanner for preclinical imaging research

    G8 PET/CT 成像系統集

    PerkinElmer 公司最新研發的 G8 PET/CT 二合一成像系統集成了高靈敏度 PET 成像及快速、低劑量 microCT 成像,使研究者在進行功能或代謝研究的同時,獲取結構性圖像數據。
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Business Insights (17)
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  • Application Note (12)
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1-12 的 17 Business Insights

  • 白皮書

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • 應用文獻

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS? high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony? software contribute to the robustness of the high-content assay.

  • 應用文獻

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • 應用文獻

    Stem Cell Research and Regenerative Medicine

    With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and grow artificial skin grafts in a lab for treatment of burn victims. Other therapeutic applications include the use of stem cells to treat and repair central nervous system diseases such as ischemia and cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including type I diabetes.

  • 應用文獻

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • 應用文獻

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • 應用文獻

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 應用文獻

    NIR Fluorescent Cell Labeling for In Vivo Cell Tracking (VivoTrack 680)

    Fluorescent dyes have been used for many years to label cells for microscopy studies, and a variety of dyes in the visible fluorescence spectrum are available to label different cellular compartments and organelles. Efficient delivery of the fluorophore to the cell without excessively modifying surface proteins or perturbing cell function is the major biotechnological challenge. In addition, researchers have taken on the challenge of in vivo imaging, focusing on near infrared (NIR) dyes that fluoresce in a spectral region better suited for in vivo imaging due to reduced background and higher tissue penetration.

  • 應用文獻

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • 應用文獻

    Preclinical Fluorescence Imaging of Cancer Metastasis to the Lung and Response to Therapy

    Quantitative pre-clinical fluorescence imaging transcends the boundaries of traditional optical imaging of biological structures and physiology by providing information at the molecular level about disease states and therapeutic response. Fluorescent Pre-clinical Imaging Agents and FMT? (Fluorescence Molecular Tomography) Quantitative Pre-clinical Imaging Systems represent powerful tools for research and drug development in the imaging of biological processes and pharmaceutical activity in living animals.

  • 應用文獻

    用高內涵篩選系統進行FRET測定

    在這個實驗中,我們建立了一種快速穩定的基于FRET的高內涵檢測...

  • 應用文獻

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera? system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

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