十三水群
PerkinElmer

心血管疾病

OF

Achieve greater visibility into the mechanisms that cause cardiovascular disease using our phenotypic and target-based solutions. We offer a broad range of products for the cardiovascular researcher.

  • Quickly and simply detect and quantitate the biomarkers of cardiovascular disease with our fast, simple, pre-validated kits and multimode plate readers
  • Effectively conduct targeted binding studies using our radiolabeled ligands and lipids
  • Probe biological processes and study treatment efficacy in animal models from molecular, functional and anatomical perspectives with our in vivo imaging systems
  • Gain deeper insights from phenotypic analysis with our high content screening solutions

產品與服務 (54)
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產品類型
  • Reagents (34)
  • Accessories (12)
  • Software and Informatics (5)
  • Instruments (3)
應用
  • Drug Discovery & Development (15)
  • Protein Analysis & Detection (11)
  • cAMP (6)
檢測點(200-50,000)
  • 500 (10)
  • 5000 (9)
  • 100 (2)
  • 10000 (1)
檢測目標
  • tPA (2)
  • Cardiac Troponin T (2)
  • PAI-1 (1)
  • D-dimer (1)
  • CHO HCP (1)
  • cardiac Troponin I (1)
  • PCSK9 (1)
  • FABP3 (1)
  • Myeloperoxidase (1)
  • Myoglobin (1)
檢測目標類
  • GPCR (21)
  • Protein (12)
檢測驗證
  • Binding (14)
  • cAMP (6)
  • Calcium Luminescence (8)
  • Downstream Phosphorylation (2)
  • Calcium Fluorescence (4)
  • GTPγS (2)
  • Inositol Phosphate (1)
自動化兼容
  • Yes (14)
濃度
  • <1.0 mCi/mL (1)
檢測方法
  • Alpha (10)
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  • Time-Resolved Fluorescence (TRF) (2)
  • Fluorescence (2)
  • TR-FRET (2)
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實驗類型
  • In vitro (11)
格式
  • Microplates (11)
宿主細胞
  • CHO-K1 (17)
  • HEK293 (4)
顯像模式
  • High Content (2)
  • microCT Imaging (1)
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  • Specifically Labeled (1)
長度
  • 51-100 (1)
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  • 901-1000 (1)
型號兼容
  • Operetta CLS (8)
  • Operetta CLS AND Opera Phenix (2)
  • Operetta (2)
產品品牌名稱
  • AlphaLISA (10)
  • Operetta CLS (9)
  • Membrane Target Systems (5)
  • ValiScreen (5)
  • AequoScreen (4)
  • AequoZen (4)
  • cAMPZen (3)
  • Operetta (2)
  • Operetta CLS AND Opera Phenix (2)
  • LANCE Ultra (2)
  • Opera Phenix (1)
  • NEN Radiochemicals (1)
  • Quantum (1)
放射性核素
  • 14C (1)
放射性同位素
  • C-14 (1)
受體類型
  • Adenosine (10)
  • Angiotensin (7)
  • Adrenergic (4)
目標種
  • Human (10)
  • CHO (1)
治療領域
  • Cardiovascular (33)
  • Inflammation (14)
  • Central Nervous System (10)
  • Angiogenesis (7)
  • Metabolic (4)
  • Gastrointestinal (4)
  • Diabetes (4)
  • Pain (4)
  • Biologics/Bioprocess (1)

1-12 的 54 產品與服務

  • 1000x1000_Opera_Phenix

    Opera Phenix 高內涵系統

    Opera Phenix?高內涵系統是目前最受期待的高內涵共聚焦技術方案。依賴將近20年的頂尖高內涵產品opera高內涵成像系統積累的豐富成像和應用經驗,新一代的opera phenix系統系統專為高內涵表型篩選以及復雜的疾病模型量身打造,例如活細胞、原代細胞,細胞微組織。
  • Quantum GX2 microCT imaging system

    Quantum GX2 microCT成像系統

    應用領域涉及骨、腫瘤、心血管和肺部等疾病研究。Quantum GX2 micro CT成像系統模式靈活,兼容離體樣本、小鼠、大鼠及兔子等多種物種;具備快速、低劑量的掃描模式,適合對活體動物進行長時程研究;具備高分辨率成像特點,能夠對離體樣本進行高分辨掃描。 Quantum GX2 microCT卓越的性能讓您不僅得到圖像,而是更深入的理解疾病模型。
  • 1000x1000_Operetta

    Operetta CLS 高內涵系統

    Operetta CLS? 系統幫助您探索常規實驗與復雜創新實驗中的生物學信息。通過一系列創新技術的有機結合,Operetta CLS? 同時滿足精細細胞細節成像對高速、高靈敏度、高分辨率檢測多方面的需求。同時,憑借功能強大的Harmony 4.5版軟件,Operetta CLS? 可幫助您發現并定量細微的細胞表型改變。
  • CHO HCP LANCE Ultra TR-FRET Detection Kit

    The LANCE??Ultra CHO HCP Detection Kit is designed for detection and quantitation of CHO host cell proteins in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
  • Receptor-expressing cell lines

    Adrenergic beta 1 AequoScreen cell line

    Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
  • PCSK9 (human) AlphaLISA Detection Kit

    The AlphaLISA? Human Proprotein Convertase Subtilisin / Kexin Type 9 (PCSK9) Detection Kit is designed for detection and quantitation of human PCSK9 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. One antibody targets the pro-domain of PCSK9.
  • Membrane Target Systems

    Membrane Target Systems: Angiotensin AT1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

    Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
  • D-dimer (human) AlphaLISA Detection Kit

    The AlphaLISA? Human D-dimer Detection Kit is designed for detection and quantitation of human D-dimer in citrate plasma, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. Please note the kit shows some cross-reactivity to D-monomer.
  • Cardiac Troponin T (human) AlphaLISA Detection Kit

    The AlphaLISA? immunoassay kit for human cardiac troponin T enables the quantitative determination of cardiac troponin T in human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
  • AlphaLISA immunoassay kits

    Tissue Plasminogen Activator (human) AlphaLISA Detection Kit

    The AlphaLISA? Human Tissue Plasminogen Activator (tPA) Detection Kit is designed for detection and quantitation of human tPA in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The kit was designed to detect both tPA and pro-tPA.
  • tPA (human) LANCE Ultra TR-FRET Detection Kit

    The LANCE? Ultra Human tPA Detection Kit is designed for detection and quantitation of human tPA in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
  • Receptor-expressing cell lines

    AequoZen FroZen cells, Angiotensin AT1, Human Recombinant, CHO-K1

    Our frozen, irradiated AequoZen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
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Business Insights (10)
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1-10 的 10 Business Insights

  • 白皮書

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • 應用文獻

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS? high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony? software contribute to the robustness of the high-content assay.

  • 應用文獻

    Contrast-enhanced Imaging of Vasculature and Soft Tissues Using the Quantum GX MicroCT System

    X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood vessels and internal organs share similar x-ray attenuation characteristics and are not distinguishable under typical CT settings. In order to introduce density that would improve soft tissue contrast, several contrast agents have been developed for use in clinical and preclinical settings. This application note outlines the use of iodine and nanoparticle-based contrast agents for imaging soft tissues and vasculature in various organs using the Quantum GX to gain further insights into disease and therapeutic response.

  • 應用文獻

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • 應用文獻

    MicroCT Investigation of Bone Erosion and Deformation in an Osteoarthritic Rat Model

    Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of bones within the joints gradually deteriorates, causing synovitis and joint deformation.

    The goal of OA research is to identify new therapeutic strategies that could prevent, reduce, halt progression, or repair the existing damage to the joint. Non-invasive in vivo imaging such as microCT is the standard modality for bone research due to its ability to obtain high-resolution images at an x-ray dose low enough as not to harm the animal. This makes microCT ideal for monitoring disease progression and response to treatments in the same animal over time. However, microCT data visualization and analysis can be cumbersome and time consuming. In this application note, we compared standard microCT software and advanced bone software to investigate bone erosion in an OA rat model.

  • 應用文獻

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 應用文獻

    用高內涵篩選系統進行FRET測定

    在這個實驗中,我們建立了一種快速穩定的基于FRET的高內涵檢測...

  • 應用文獻

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera? system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • 應用文獻

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • 案例分析

    High-Content Analysis of Drug-Induced Oligodendrocyte Differentiation Promoting Remyelination in Multiple Sclerosis

    One of the greatest challenges in multiple sclerosis (MS) therapy is the halting or reversal of the failure of remyelination in the brain in order to reverse disabilities in MS patients. This case study highlights the recent work of Dr. Paul Tesar and colleagues at the Case Western Reserve University School of Medicine, which could potentially lead to such novel treatments, as it aims to control the function of stem cells in the body and thereby to help the body repair itself.

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