十三水群
PerkinElmer

細胞學研究

OF

獲取原代細胞、活細胞、3D培養細胞的新視野。我們提供一系列檢測設備、實驗和試劑,高內涵分析系統,信息學服務,自動化解決方案幫助您從如此細胞學研究中獲取高質量的數據信息,幫助您獲取可重復、可定量的優質數據。

  • 獲取細胞信號通路和功能的新發現。我們提供廣泛的可供選擇的技術方案、實驗和試劑以及多功能酶標儀幫助您進行進一步的實驗驗證。
  • 通過高內涵分析系統洞察細胞表型變化并獲取豐富細胞學參數信息。
  • 通過我們自動化縝合方案加速您的細胞學研究。
  • 通過我們功能強大的信息學方案分析和可視化呈現您的細胞學數據以更進一步進行信息和知識的深度挖掘。

產品與服務 (50)
Filters:

Filters :

產品類型
  • Accessories (44)
  • Consumables (2)
  • Software and Informatics (2)
  • Instruments (2)
自動化兼容
  • Yes (2)
檢測方法
  • Transmission (2)
  • Fluorescence (2)
顯像模式
  • High Content (2)
長度
  • 51-100 (1)
  • 101-200 (1)
型號兼容
  • Operetta (30)
  • Operetta CLS AND Opera Phenix (10)
  • Operetta CLS (8)
產品品牌名稱
  • Operetta (29)
  • Operetta CLS AND Opera Phenix (9)
  • Operetta CLS (9)
  • Opera Phenix (1)

1-12 的 50 產品與服務

  • Jump to:
Business Insights (7)
Filters:

1-7 的 7 Business Insights

  • 應用文獻

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera? system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • 應用文獻

    用高內涵篩選系統進行FRET測定

    在這個實驗中,我們建立了一種快速穩定的基于FRET的高內涵檢測...

  • 應用文獻

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS? high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony? software contribute to the robustness of the high-content assay.

  • 應用文獻

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 應用文獻

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • 應用文獻

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • 案例分析

    High-Content Analysis of Drug-Induced Oligodendrocyte Differentiation Promoting Remyelination in Multiple Sclerosis

    One of the greatest challenges in multiple sclerosis (MS) therapy is the halting or reversal of the failure of remyelination in the brain in order to reverse disabilities in MS patients. This case study highlights the recent work of Dr. Paul Tesar and colleagues at the Case Western Reserve University School of Medicine, which could potentially lead to such novel treatments, as it aims to control the function of stem cells in the body and thereby to help the body repair itself.

十三水群