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PerkinElmer

高內涵篩選儀器和顯微鏡

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獲得您需要的靈敏度和速度,可以對更多樣品進行快速檢測,并通過高內涵篩選分析獲取更多參數。 我們的高內涵篩選分析系統可幫助您回答錯綜復雜的生物學問題,憑借功能強大且界面友好的成像和分析功能,該系統可靈活應用于從基礎科研到實驗模型開發以及藥物篩選的一系列應用 -這些功能強大的高內涵顯微鏡系統為您提供了前所未有的高內涵篩選圖像質量, 結合PerkinElmer的自動化系統和強大高級數據分析解決方案, 該體系將快速助力您的科研工作更上一層樓。 僅系統僅供研究使用。 不用于診斷程序。

產品與服務 (3)
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1-3 的 3 產品與服務

  • Operetta FrontAngle green copy

    Operetta 高內涵系統

    隨著科學家對于復雜生物問題探討的日益加深,研究者對于大規模復雜的生物學模型的需求要越來越廣泛。所以他們選擇了Operetta CLS? 高內涵篩選系統-對于健康或疾病細胞內部機制研究的理想工具。
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  • 1000x1000_Opera_Phenix

    Opera Phenix 高內涵系統

    Opera Phenix?高內涵系統是目前最受期待的高內涵共聚焦技術方案。依賴將近20年的頂尖高內涵產品opera高內涵成像系統積累的豐富成像和應用經驗,新一代的opera phenix系統系統專為高內涵表型篩選以及復雜的疾病模型量身打造,例如活細胞、原代細胞,細胞微組織。
  • 1000x1000_Operetta

    Operetta CLS 高內涵系統

    Operetta CLS? 系統幫助您探索常規實驗與復雜創新實驗中的生物學信息。通過一系列創新技術的有機結合,Operetta CLS? 同時滿足精細細胞細節成像對高速、高靈敏度、高分辨率檢測多方面的需求。同時,憑借功能強大的Harmony 4.5版軟件,Operetta CLS? 可幫助您發現并定量細微的細胞表型改變。
Business Insights (7)
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1-7 的 7 Business Insights

  • 應用文獻

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera? system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • 應用文獻

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • 應用文獻

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • 應用文獻

    用高內涵篩選系統進行FRET測定

    在這個實驗中,我們建立了一種快速穩定的基于FRET的高內涵檢測...

  • 應用文獻

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS? high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony? software contribute to the robustness of the high-content assay.

  • 應用文獻

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 案例分析

    High-Content Analysis of Drug-Induced Oligodendrocyte Differentiation Promoting Remyelination in Multiple Sclerosis

    One of the greatest challenges in multiple sclerosis (MS) therapy is the halting or reversal of the failure of remyelination in the brain in order to reverse disabilities in MS patients. This case study highlights the recent work of Dr. Paul Tesar and colleagues at the Case Western Reserve University School of Medicine, which could potentially lead to such novel treatments, as it aims to control the function of stem cells in the body and thereby to help the body repair itself.

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