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PerkinElmer

安全/毒理學

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通過我們的藥代動力學(PK)表征功效解決方案,確保患者安全,避免接觸危險藥品和藥物代謝物水平。這些產品可幫助您在將備選藥物用于人體前對藥物進行最終評估,并且可以幫助您選用最佳的臨床評估起始劑量。

我們的定制放射性標記服務和活體內功效值得您的信賴。

產品與服務 (56)
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產品類型
  • Accessories (37)
  • Instruments (10)
  • Software and Informatics (4)
  • Reagents (3)
  • Consumables (2)
檢測點(200-50,000)
  • 300 (1)
自動化兼容
  • Yes (6)
檢測方法
  • Luminescence (5)
  • Time-Resolved Fluorescence (TRF) (4)
  • Fluorescence (4)
  • Absorbance (3)
  • Fluorescence Polarization (2)
  • Alpha (2)
  • Image-based Cytometry (1)
  • Transmission (1)
  • DELFIA TRF (1)
實驗類型
  • In vitro (1)
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  • Microplates (1)
顯像模式
  • Optical Imaging (5)
  • microCT Imaging (2)
  • High Content (1)
長度
  • 51-100 (5)
  • 101-200 (1)
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溫度-最高
  • 40-50 (2)
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型號兼容
  • Operetta (30)
  • Operetta CLS AND Opera Phenix (8)
產品品牌名稱
  • Operetta (29)
  • Operetta CLS AND Opera Phenix (7)
  • IVIS (5)
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  • ATPlite 3D (2)
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  • Opera Phenix (1)
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  • Victor (1)
  • DELFIA (1)

1-12 的 56 產品與服務

  • EnSight Multimode Plate Reader

    EnSight 多模式讀板儀

    EnSight? 多模式讀板儀是一臺整合了多標記、無標記和顯微成像技術的桌面式一體化檢測平臺。其整孔成像&在線數據分析速度非常快,可以在五分鐘內完成384孔板整板的圖像獲取及分析。該儀器采用預置模塊化設計,結合基于Kaleido軟件的數據采集和分析流程,是一臺真正的全能且高產的多模式讀板儀。
  • 1000x1000_Opera_Phenix

    Opera Phenix 高內涵系統

    Opera Phenix?高內涵系統是目前最受期待的高內涵共聚焦技術方案。依賴將近20年的頂尖高內涵產品opera高內涵成像系統積累的豐富成像和應用經驗,新一代的opera phenix系統系統專為高內涵表型篩選以及復雜的疾病模型量身打造,例如活細胞、原代細胞,細胞微組織。
  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS 小動物活體成像系統

    IVIS? Lumina XRMS III是PerkinElmer最新推出的二維多模式活體成像系統,具備最高靈敏度的生物發光、多光譜熒光、放射性同位素和X光活體成像功能。
  • Quantum GX2 microCT imaging system

    Quantum GX2 microCT成像系統

    應用領域涉及骨、腫瘤、心血管和肺部等疾病研究。Quantum GX2 micro CT成像系統模式靈活,兼容離體樣本、小鼠、大鼠及兔子等多種物種;具備快速、低劑量的掃描模式,適合對活體動物進行長時程研究;具備高分辨率成像特點,能夠對離體樣本進行高分辨掃描。 Quantum GX2 microCT卓越的性能讓您不僅得到圖像,而是更深入的理解疾病模型。
  • EnVision 2105 multimode plate reader

    EnVision 多模式讀板儀

    EnVision 多模式讀板儀在所有檢測模式下都能提供最快的檢測速度、超高通量及最高的靈敏度,為您的高通量篩選提供可靠的儀器及結果,以滿足您日益加速的新實驗需求。
  • IVIS Spectrum In Vivo Imaging System

    IVIS Spectrum 小動物活體成像系統

    IVIS? Spectrum 小動物活體光學成像系統是全球首臺同時具備生物發光、熒光、化學發光及切倫科夫二維/三維成像功能的系統,代表了目前活體光學成像技術的最高水平。
  • VictorX_ImageA_320px

    VICTOR 多模式讀板儀

    新一代的 VICTOR X 系列多模式讀板儀為各種規模的實驗室提供集靈活性、高速度和高性能于一體的解決方案。
  • IVIS SpectrumCT 2D/3D Optical/CT In Vivo Imaging System

    IVIS SpectrumCT 小動物活體成像系統

    IVIS? Spectrum CT是全球頂尖的小動物活體三維光學/CT二合一成像系統。
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina III 小動物活體成像系統

    IVIS? Lumina III是PerkinElmer最新推出的第三代高靈敏度多光譜小動物活體光學二維成像平臺。
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina LT 小動物活體成像系統

    IVIS? Lumina LT是PerkinElmer最新推出的第三代高靈敏度小動物活體光學二維成像平臺。
  • ATPlite 1-step 3D kit

    ATPlite 1Step 3D, 10 mL kit

    ATP-monitoring luminescence assay for quantitative evaluation of proliferation and cytotoxicity of mammalian cells cultured in 3D spheroids. The 1-step format only requires one addition step, and can be used for continuous processing.
  • ATPlite 3D Kit

    ATPlite 3D, 300 assay point kit

    ATP-monitoring luminescence assay for quantitative evaluation of proliferation and cytotoxicity of mammalian cells cultured in 3D spheroids.
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Business Insights (16)
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資源庫
  • Application Note (12)
  • Poster (3)
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1-12 的 16 Business Insights

  • 白皮書

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • 應用文獻

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS? high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony? software contribute to the robustness of the high-content assay.

  • 應用文獻

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • 應用文獻

    Contrast-enhanced Imaging of Vasculature and Soft Tissues Using the Quantum GX MicroCT System

    X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood vessels and internal organs share similar x-ray attenuation characteristics and are not distinguishable under typical CT settings. In order to introduce density that would improve soft tissue contrast, several contrast agents have been developed for use in clinical and preclinical settings. This application note outlines the use of iodine and nanoparticle-based contrast agents for imaging soft tissues and vasculature in various organs using the Quantum GX to gain further insights into disease and therapeutic response.

  • 應用文獻

    Stem Cell Research and Regenerative Medicine

    With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and grow artificial skin grafts in a lab for treatment of burn victims. Other therapeutic applications include the use of stem cells to treat and repair central nervous system diseases such as ischemia and cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including type I diabetes.

  • 應用文獻

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • 應用文獻

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • 應用文獻

    MicroCT Investigation of Bone Erosion and Deformation in an Osteoarthritic Rat Model

    Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of bones within the joints gradually deteriorates, causing synovitis and joint deformation.

    The goal of OA research is to identify new therapeutic strategies that could prevent, reduce, halt progression, or repair the existing damage to the joint. Non-invasive in vivo imaging such as microCT is the standard modality for bone research due to its ability to obtain high-resolution images at an x-ray dose low enough as not to harm the animal. This makes microCT ideal for monitoring disease progression and response to treatments in the same animal over time. However, microCT data visualization and analysis can be cumbersome and time consuming. In this application note, we compared standard microCT software and advanced bone software to investigate bone erosion in an OA rat model.

  • 應用文獻

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • 應用文獻

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • 應用文獻

    用高內涵篩選系統進行FRET測定

    在這個實驗中,我們建立了一種快速穩定的基于FRET的高內涵檢測...

  • 應用文獻

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera? system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

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